China GMP Quality Factory Direct Supply 99% Purity ACTH (1-24) Peptides Raw Lyophilized Powder CAS 16960 -16-0

Origin
China
HS Code
3001200020
Production Capacity
50 Mt/Year
Reference Price
$ 9.00 - 45.00
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Product Description

 

Product Description

Product Name:Tetracosactide,Cosyntropin,Tetracosactrin,acortan
Alias: AC TH (1-24), HUMAN; AC TH (1-24) (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT); AC TH (1-24);
Purity: 99%
CAS Registry Number: 16960-16-0
Einecs No: 241-031-1
MF: C136H210N40O31S
MW: 2933.47
Melting point: 2 ° C
Boiling point: 225° C
Refractive index: 1.551-1.553
Appearance: White powder
Grade: Pharmceutical Grade
Storage: Shading, confined preservation
Usage: Cosyntropin (cortrosyn) is a synthetic derivative of adrenocorticotropic hormone (AC TH) that is used in the AC TH stimulation test to evaluate and diagnose cortisol disorders.

Product Introduction

Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. AC TH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural AC TH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.

Product Usage

Cosyntropin exhibits the full corticosteroidogenic activity of natural AC TH. Various studies have shown that the biologic activity of AC TH resides in the N- terminal portion of the molecule and that the 1-20 amino acid residue is the minimal sequence retaining full activity. Partial or complete loss of activity is noted with progressive shortening of the chain beyond 20 amino acid residue. For example, the decrement from 20 to 19 results in a 70% loss of potency. The pharmacologic profile of Cosyntropin is similar to that of purified natural AC TH. It has been established that 0.25 mg of Cosyntropin will stimulate the adrenal cortex maximally and to the same extent as 25 units of natural AC TH. Cosyntropin has less immunogenic activity than AC TH because the amino acid sequence having most of the antigenic activity of AC TH, i.e., amino acids 25-39, is not present in cosyntropin. The extra-adrenal effects which natural AC TH and Cosyntropin have in common include increased melanotropic activity, increased grow hormone secretion and an adipokinetic effect. These are considered to be without physiological or clinical significance.

Tags

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China GMP Quality Factory Direct Supply 99% Purity ACTH (1-24) Peptides Raw Lyophilized Powder CAS 16960-16-0

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China GMP Quality Factory Direct Supply 99% Purity ACTH (1-24) Peptides Raw Lyophilized Powder CAS 16960-16-0

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China GMP Quality Factory Direct Supply 99% Purity ACTH (1-24) Peptides Raw Lyophilized Powder CAS 16960-16-0

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